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Target
Diacylglycerol lipase-beta
Ligand
BDBM434879
Substrate
n/a
Meas. Tech.
ChEMBL_1924060 (CHEMBL4427016)
IC50
7.9±n/a nM
Citation
 Janssen, FJ; van der Stelt, M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. Bioorg Med Chem Lett 26:3831-7 (2016) [PubMed]  Article 
Target
Name:
Diacylglycerol lipase-beta
Synonyms:
DGL-beta | DGLB_MOUSE | Daglb | Sn1-specific diacylglycerol lipase beta
Type:
PROTEIN
Mol. Mass.:
73906.34
Organism:
Mus musculus
Description:
ChEMBL_101275
Residue:
669
Sequence:
MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLIVLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNRLLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTLLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLVNDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLYEYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSPDNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSCPGQGGSSVP
  
Inhibitor
Name:
BDBM434879
Synonyms:
US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H28F3N5O4
Mol. Mass.:
531.5268
SMILES:
CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Structure:
Search PDB for entries with ligand similarity: