Reaction Details Report a problem with these data
Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50533136
Substrate
n/a
Meas. Tech.
ChEMBL_1924454 (CHEMBL4427410)
IC50
8.0±n/a nM
Citation
Cheng, D; Liu, J; Han, D; Zhang, G; Gao, W; Hsieh, MH; Ng, N; Kasibhatla, S; Tompkins, C; Li, J; Steffy, A; Sun, F; Li, C; Seidel, HM; Harris, JL; Pan, S Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett 7:676-80 (2016) [PubMed] Article
More Info.:
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine
Type:
PROTEIN
Mol. Mass.:
52337.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103574
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG