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Target
Hexokinase-4
Ligand
BDBM50533152
Substrate
n/a
Meas. Tech.
ChEMBL_1924594 (CHEMBL4427550)
EC50
13200±n/a nM
Citation
 Dransfield, PJ; Pattaropong, V; Lai, S; Fu, Z; Kohn, TJ; Du, X; Cheng, A; Xiong, Y; Komorowski, R; Jin, L; Conn, M; Tien, E; DeWolf, WE; Hinklin, RJ; Aicher, TD; Kraser, CF; Boyd, SA; Voegtli, WC; Condroski, KR; Veniant-Ellison, M; Medina, JC; Houze, J; Coward, P Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett 7:714-8 (2016) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50533152
Synonyms:
CHEMBL4444820
Type:
Small organic molecule
Emp. Form.:
C19H19N5O4
Mol. Mass.:
381.3853
SMILES:
CNC(=O)Nc1cc(Oc2ccccn2)c(cn1)-c1ccc(OCCO)nc1
Structure:
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