Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50533167
Substrate
n/a
Meas. Tech.
ChEMBL_1924594 (CHEMBL4427550)
EC50
1300±n/a nM
Citation
 Dransfield, PJ; Pattaropong, V; Lai, S; Fu, Z; Kohn, TJ; Du, X; Cheng, A; Xiong, Y; Komorowski, R; Jin, L; Conn, M; Tien, E; DeWolf, WE; Hinklin, RJ; Aicher, TD; Kraser, CF; Boyd, SA; Voegtli, WC; Condroski, KR; Veniant-Ellison, M; Medina, JC; Houze, J; Coward, P Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett 7:714-8 (2016) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50533167
Synonyms:
CHEMBL4572115
Type:
Small organic molecule
Emp. Form.:
C21H23N5O5
Mol. Mass.:
425.4378
SMILES:
CCOc1cncc(Oc2cc(NC(=O)NC)ncc2-c2ccc(OCCO)nc2)c1
Structure:
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