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Target
Beta-lactamase
Ligand
BDBM50088808
Substrate
n/a
Meas. Tech.
ChEMBL_41055 (CHEMBL648219)
IC50
230000±n/a nM
Citation
 Buynak, JD; Doppalapudi, VR; Rao, AS; Nidamarthy, SD; Adam, G The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett 10:847-51 (2000) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
BLAC_STAAU | Beta-lactamase TEM | Penicillinase | blaZ
Type:
PROTEIN
Mol. Mass.:
31367.53
Organism:
Staphylococcus aureus
Description:
ChEMBL_41052
Residue:
281
Sequence:
MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYVGKDITLKALIEASMTYSDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKTLNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASRNDVAFVYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF
  
Inhibitor
Name:
BDBM50088808
Synonyms:
CHEMBL355571 | [(R)-3-Acetoxymethyl-2-carboxy-4-methylene-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-en-(7Z)-ylidene]-acetic acid anion; Disodium
Type:
Small organic molecule
Emp. Form.:
C13H9NO9S
Mol. Mass.:
355.278
SMILES:
CC(=O)OCC1=C(N2[C@@H](\C(=C/C([O-])=O)C2=O)S(=O)(=O)C1=C)C([O-])=O |t:5|
Structure:
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