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Target
Endothelin-1 receptor
Ligand
BDBM50088853
Substrate
n/a
Meas. Tech.
ChEBML_65626
IC50
2500±n/a nM
Citation
 Kraus, GA; Wang, X Synthesis and endothelin receptor binding activity of synthetic analogues of RES-1149-2. Bioorg Med Chem Lett 10:895-7 (2000) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50088853
Synonyms:
(2E,4E)-Hexa-2,4-dienoic acid (5S,7aS)-1,7a-dihydroxy-1,3,5,6,7,7a-hexahydro-isobenzofuran-5-yl ester | CHEMBL173336
Type:
Small organic molecule
Emp. Form.:
C14H18O5
Mol. Mass.:
266.2897
SMILES:
C\C=C\C=C\C(=O)O[C@H]1CC[C@@]2(O)C(O)OCC2=C1 |c:18|
Structure:
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