Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM294298
Substrate
n/a
Meas. Tech.
ChEMBL_1924896
IC50
478±n/a nM
Citation
 Hanisak, JSeganish, WMMcElroy, WTTang, HZhang, RTsui, HCFischmann, TTulshian, DTata, JSondey, CDevito, KFossetta, JGarlisi, CGLundell, DNiu, X Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors. Bioorg Med Chem Lett 26:4250-5 (2016) [PubMed]  Article
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM294298
Synonyms:
US9586948, Example 17
Type:
Small organic molecule
Emp. Form.:
C22H25N7O3
Mol. Mass.:
435.479
SMILES:
Cn1cc(NC(=O)c2cccc(n2)-c2ccnc(NCC3CCOCC3)c2)c(n1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: