Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50089042
Substrate
n/a
Meas. Tech.
ChEBML_143988
IC50
390±n/a nM
Citation
 Rueeger, H; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Schilling, W; Criscione, L; Whitebread, S; Chiesi, M; Walker, MW; Dhanoa, D; Islam, I; Zhang, J; Gluchowski, C Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 10:1175-9 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50089042
Synonyms:
CHEMBL17398 | N-{4-[4-(4-Chloro-phenylamino)-quinazolin-2-ylamino]-cyclohexylmethyl}-acetamide
Type:
Small organic molecule
Emp. Form.:
C23H26ClN5O
Mol. Mass.:
423.938
SMILES:
CC(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(Cl)cc2)c2ccccc2n1 |wU:8.11,wD:5.4,(15.06,-7.1,;13.73,-6.33,;12.4,-7.1,;13.73,-4.79,;12.39,-4.02,;11.06,-4.79,;9.71,-4.02,;8.38,-4.81,;8.4,-6.35,;9.73,-7.1,;11.06,-6.33,;7.07,-7.12,;5.72,-6.35,;5.72,-4.81,;4.37,-4.04,;4.37,-2.5,;5.7,-1.73,;7.03,-2.5,;8.36,-1.71,;8.35,-.17,;9.68,.6,;7.01,.58,;5.68,-.19,;3.06,-4.81,;1.71,-4.04,;.38,-4.81,;.38,-6.37,;1.71,-7.14,;3.06,-6.35,;4.39,-7.12,)|
Structure:
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