Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50089064
Substrate
n/a
Meas. Tech.
ChEBML_143988
IC50
710±n/a nM
Citation
 Rueeger, H; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Schilling, W; Criscione, L; Whitebread, S; Chiesi, M; Walker, MW; Dhanoa, D; Islam, I; Zhang, J; Gluchowski, C Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 10:1175-9 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50089064
Synonyms:
CHEMBL275845 | Naphthalene-1-sulfonic acid (4-{[(4-amino-quinazolin-2-yl)-methyl-amino]-methyl}-cyclohexylmethyl)-methyl-amide
Type:
Small organic molecule
Emp. Form.:
C28H33N5O2S
Mol. Mass.:
503.659
SMILES:
CN(C[C@H]1CC[C@H](CN(C)S(=O)(=O)c2cccc3ccccc23)CC1)c1nc(N)c2ccccc2n1 |wU:3.2,wD:6.6,(2.68,-4.08,;2.68,-2.54,;4.02,-1.77,;5.35,-2.53,;6.69,-1.76,;8.02,-2.54,;8,-4.08,;9.33,-4.86,;10.83,-4.45,;10.61,-5.93,;12.15,-5.22,;12.13,-6.76,;12.13,-3.68,;13.69,-5.22,;14.02,-3.71,;15.5,-3.27,;16.63,-4.31,;16.28,-5.81,;17.42,-6.85,;17.07,-8.35,;15.61,-8.81,;14.48,-7.76,;14.81,-6.26,;6.68,-4.83,;5.35,-4.06,;1.34,-1.76,;1.34,-.21,;-.02,.55,;-.02,2.1,;-1.34,-.22,;-2.68,.55,;-4.03,-.22,;-4.03,-1.78,;-2.68,-2.55,;-1.34,-1.77,;.01,-2.55,)|
Structure:
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