Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50089070
Substrate
n/a
Meas. Tech.
ChEBML_143988
IC50
4±n/a nM
Citation
 Rueeger, H; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Schilling, W; Criscione, L; Whitebread, S; Chiesi, M; Walker, MW; Dhanoa, D; Islam, I; Zhang, J; Gluchowski, C Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 10:1175-9 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50089070
Synonyms:
4-Methyl-N-[4-(4-phenylamino-quinazolin-2-ylamino)-cyclohexylmethyl]-benzenesulfonamide | CHEMBL17521
Type:
Small organic molecule
Emp. Form.:
C28H31N5O2S
Mol. Mass.:
501.643
SMILES:
Cc1ccc(cc1)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccccc2)c2ccccc2n1 |wU:15.19,wD:12.12,(17.79,-13.14,;17.4,-11.66,;18.48,-10.56,;18.07,-9.09,;16.61,-8.7,;15.52,-9.79,;15.91,-11.26,;16.21,-7.22,;14.86,-7.98,;17.62,-7.38,;16.21,-5.68,;14.86,-4.91,;13.54,-5.68,;12.19,-4.91,;10.86,-5.68,;10.87,-7.23,;12.21,-7.98,;13.54,-7.22,;9.54,-8.01,;8.21,-7.23,;8.19,-5.68,;6.86,-4.91,;6.84,-3.38,;8.17,-2.59,;8.16,-1.07,;9.49,-.29,;10.83,-1.05,;10.84,-2.59,;9.51,-3.37,;5.53,-5.7,;4.19,-4.93,;2.86,-5.7,;2.86,-7.24,;4.19,-8.02,;5.53,-7.24,;6.87,-8.01,)|
Structure:
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