Reaction Details Report a problem with these data
Target
Neuroendocrine convertase 2
Ligand
BDBM50533413
Substrate
n/a
Meas. Tech.
ChEMBL_1925258 (CHEMBL4428330)
Ki
0.360000±n/a nM
Citation
 Kumar, R; Juillerat-Jeanneret, L; Golshayan, D Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. J Med Chem 59:7719-37 (2016) [PubMed]  Article 
Target
Name:
Neuroendocrine convertase 2
Synonyms:
KEX2-like endoprotease 2 | NEC 2 | NEC2 | NEC2_HUMAN | Neuroendocrine convertase 2 | PC2 | PCSK2 | Prohormone convertase 2 | Proprotein convertase 2
Type:
PROTEIN
Mol. Mass.:
70563.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290738
Residue:
638
Sequence:
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
  
Inhibitor
Name:
BDBM50533413
Synonyms:
CHEMBL3126388
Type:
Small organic molecule
Emp. Form.:
C34H66ClN11O5
Mol. Mass.:
744.412
SMILES:
CCCCCCCCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl |r|
Structure:
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