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Target
Adenosine kinase
Ligand
BDBM50533467
Substrate
n/a
Meas. Tech.
ChEMBL_1925616 (CHEMBL4428688)
IC50
40±n/a nM
Citation
 Toti, KS; Osborne, D; Ciancetta, A; Boison, D; Jacobson, KA South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase. J Med Chem 59:6860-77 (2016) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50533467
Synonyms:
CHEMBL4441282
Type:
Small organic molecule
Emp. Form.:
C10H12IN5O4
Mol. Mass.:
393.1379
SMILES:
Nc1ncnc2n(nc(I)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure:
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