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Target
Acetylcholinesterase
Ligand
BDBM50089506
Substrate
n/a
Meas. Tech.
ChEBML_28133
Ki
50900±n/a nM
Citation
 Moon, SC; Shin, JH; Jeong, BH; Kim, HS; Yu, BS; Lee, JS; Lee, BS; Namgoong, SK Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett 10:1435-8 (2000) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electrophorus electricus (Electric eel)
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM50089506
Synonyms:
(1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2-fluoro-phenyl)-porphyrin | CHEMBL285169
Type:
Small organic molecule
Emp. Form.:
C44H26F4N4
Mol. Mass.:
686.6977
SMILES:
Fc1ccccc1-c1c2ccc(n2)c(-c2ccccc2F)c2ccc([nH]2)c(-c2ccccc2F)c2ccc([nH]2)c(-c2ccccc2F)c2ccc1n2 |(16.72,-24.42,;15.37,-25.15,;15.33,-26.69,;13.98,-27.43,;12.66,-26.62,;12.7,-25.08,;14.05,-24.35,;14.1,-22.81,;15.45,-22.07,;16.84,-22.72,;17.9,-21.61,;17.17,-20.25,;15.66,-20.53,;18.01,-18.97,;19.55,-19.04,;20.24,-20.42,;21.79,-20.49,;22.62,-19.18,;21.91,-17.83,;20.37,-17.75,;19.67,-16.38,;17.17,-17.43,;17.94,-16.1,;16.89,-14.96,;15.49,-15.59,;15.66,-17.12,;14.16,-14.82,;14.16,-13.28,;12.83,-12.51,;12.83,-10.96,;14.16,-10.19,;15.49,-10.96,;15.49,-12.51,;16.82,-13.28,;12.83,-15.59,;11.41,-14.96,;10.39,-16.1,;11.16,-17.45,;12.66,-17.13,;10.39,-18.78,;8.85,-18.78,;8.08,-17.45,;6.54,-17.45,;5.77,-18.8,;6.54,-20.14,;8.08,-20.14,;8.85,-21.47,;11.16,-20.11,;10.36,-21.42,;11.36,-22.58,;12.79,-22,;12.66,-20.46,)|
Structure:
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