Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50534272
Substrate
n/a
Meas. Tech.
ChEMBL_1928081 (CHEMBL4431153)
IC50
10.0±n/a nM
Citation
 Giordanetto, F; Pettersen, D; Starke, I; Nordberg, P; Dahlström, M; Knerr, L; Selmi, N; Rosengren, B; Larsson, LO; Sandmark, J; Castaldo, M; Dekker, N; Karlsson, U; Hurt-Camejo, E Discovery of AZD2716: A Novel Secreted Phospholipase A ACS Med Chem Lett 7:884-889 (2016) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
Group IIA phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | GIIC sPLA2 | Non-Pancreatic Secretory Phospholipase A2 | Phosphatidylcholine 2-acylhydrolase | NPS-PLA2 | PA2GA_HUMAN | PLA2G2A | PLA2B | PLA2L | RASF-A | Phospholipase A2 group IIA
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Human
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50534272
Synonyms:
CHEMBL4593409
Type:
Small organic molecule
Emp. Form.:
C24H23NO3
Mol. Mass.:
373.45
SMILES:
C[C@H](Cc1cccc(c1)-c1cc(Cc2ccccc2)ccc1C(N)=O)C(O)=O |r|
Structure:
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