Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50534347
Substrate
n/a
Meas. Tech.
ChEMBL_1928186 (CHEMBL4431258)
IC50
4.0±n/a nM
Citation
 Ingham, OJ; Paranal, RM; Smith, WB; Escobar, RA; Yueh, H; Snyder, T; Porco, JA; Bradner, JE; Beeler, AB Development of a Potent and Selective HDAC8 Inhibitor. ACS Med Chem Lett 7:929-932 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50534347
Synonyms:
CHEMBL4476253
Type:
Small organic molecule
Emp. Form.:
C20H18N4O2S
Mol. Mass.:
378.448
SMILES:
ONC(=O)[C@H](Cc1ccccc1)n1nnc(-c2ccsc2)c1C#CC1CC1 |r|
Structure:
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