Reaction Details Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM50090041
Substrate
n/a
Meas. Tech.
ChEMBL_33736 (CHEMBL647052)
Ki
0.75±n/a nM
Citation
Barrow, JC; Nantermet, PG; Selnick, HG; Glass, KL; Rittle, KE; Gilbert, KF; Steele, TG; Homnick, CF; Freidinger, RM; Ransom, RW; Kling, P; Reiss, D; Broten, TP; Schorn, TW; Chang, RS; O'Malley, SS; Olah, TV; Ellis, JD; Barrish, A; Kassahun, K; Leppert, P; Nagarathnam, D; Forray, C In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia. J Med Chem 43:2703-18 (2000) [PubMed] Article
More Info.:
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Inhibitor
Name:
BDBM50090041
Synonyms:
6-(3,4-Difluoro-phenyl)-5-{3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propylcarbamoyl}-3,4-dimethyl-2-oxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid methyl ester | CHEMBL93623
Type:
Small organic molecule
Emp. Form.:
C29H33F3N4O4
Mol. Mass.:
558.5919
SMILES:
COC(=O)N1[C@@H](C(C(=O)NCCCN2CCC(CC2)c2ccc(F)cc2)=C(C)N(C)C1=O)c1ccc(F)c(F)c1 |t:27|