Reaction Details Report a problem with these data
Target
Folate receptor alpha
Ligand
BDBM50534426
Substrate
n/a
Meas. Tech.
ChEMBL_1928966 (CHEMBL4432142)
IC50
1.1±n/a nM
Citation
Golani, LK; Wallace-Povirk, A; Deis, SM; Wong, J; Ke, J; Gu, X; Raghavan, S; Wilson, MR; Li, X; Polin, L; de Waal, PW; White, K; Kushner, J; O'Connor, C; Hou, Z; Xu, HE; Melcher, K; Dann, CE; Matherly, LH; Gangjee, A Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 59:7856-76 (2016) [PubMed] Article
More Info.:
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS