Reaction Details Report a problem with these data
Target
Triosephosphate isomerase, glycosomal
Ligand
BDBM50534547
Substrate
n/a
Meas. Tech.
ChEMBL_1929124 (CHEMBL4432300)
IC50
223000±n/a nM
Citation
 Velázquez-López, JM; Hernández-Campos, A; Yépez-Mulia, L; Téllez-Valencia, A; Flores-Carrillo, P; Nieto-Meneses, R; Castillo, R Synthesis and trypanocidal activity of novel benzimidazole derivatives. Bioorg Med Chem Lett 26:4377-81 (2016) [PubMed]  Article 
Target
Name:
Triosephosphate isomerase, glycosomal
Synonyms:
TIM | TPIS_TRYCR | Triose-phosphate isomerase
Type:
PROTEIN
Mol. Mass.:
27334.70
Organism:
Trypanosoma cruzi
Description:
ChEMBL_596695
Residue:
251
Sequence:
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
  
Inhibitor
Name:
BDBM50534547
Synonyms:
CHEMBL4443832
Type:
Small organic molecule
Emp. Form.:
C14H11ClN4O3S2
Mol. Mass.:
382.845
SMILES:
COC(=O)c1cc2nc(SCC(=O)Nc3nccs3)[nH]c2cc1Cl
Structure:
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