Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50534875
Substrate
n/a
Meas. Tech.
ChEMBL_1929482 (CHEMBL4432658)
IC50
250±n/a nM
Citation
 Greig, IR; Baillie, GL; Abdelrahman, M; Trembleau, L; Ross, RA Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators. Bioorg Med Chem Lett 26:4403-4407 (2016) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50534875
Synonyms:
CHEMBL4466826
Type:
Small organic molecule
Emp. Form.:
C17H15F3N2O2S
Mol. Mass.:
368.373
SMILES:
Cc1c([nH]c2ccccc12)S(=O)(=O)NCc1ccc(cc1)C(F)(F)F
Structure:
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