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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50090746
Substrate
n/a
Meas. Tech.
ChEMBL_71731 (CHEMBL680410)
IC50
88±n/a nM
Citation
 Yahalom, D; Rahimipour, S; Koch, Y; Ben-Aroya, N; Fridkin, M Design and synthesis of potent hexapeptide and heptapeptide gonadotropin-releasing hormone antagonists by truncation of a decapeptide analogue sequence. J Med Chem 43:2831-6 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50090746
Synonyms:
1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-propionylamino)-3-(4-chloro-phenyl)-propionylamino]-3-pyridin-2-yl-propionylamino}-propionylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-ethyl)-amide | CHEMBL317721
Type:
Small organic molecule
Emp. Form.:
C49H60ClN9O8
Mol. Mass.:
938.509
SMILES:
CCCCC(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Structure:
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