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Target
Adenosine kinase
Ligand
BDBM50090866
Substrate
n/a
Meas. Tech.
ChEMBL_31114 (CHEMBL642225)
IC50
70.0±n/a nM
Citation
 Ugarkar, BG; DaRe, JM; Kopcho, JJ; Browne, CE; Schanzer, JM; Wiesner, JB; Erion, MD Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem 43:2883-93 (2000) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50090866
Synonyms:
(2R,3R,4S,5R)-2-(4-Chloro-5-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol | (2R,3R,4S,5R)-2-(4-chloro-5-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydrofuran-3,4-diol | 2-(4-Chloro-5-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol | CHEMBL318056
Type:
Small organic molecule
Emp. Form.:
C12H14ClN3O3S
Mol. Mass.:
315.776
SMILES:
CSc1cn([C@@H]2O[C@H](C)[C@@H](O)[C@H]2O)c2ncnc(Cl)c12 |r|
Structure:
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