Reaction Details Report a problem with these data
Target
Adenosine 5'-monophosphoramidase HINT1
Ligand
BDBM50535045
Substrate
n/a
Meas. Tech.
ChEMBL_1929727 (CHEMBL4432903)
Kd
810±n/a nM
Citation
 Shah, R; Strom, A; Zhou, A; Maize, KM; Finzel, BC; Wagner, CR Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. ACS Med Chem Lett 7:780-4 (2016) [PubMed]  Article 
Target
Name:
Adenosine 5'-monophosphoramidase HINT1
Synonyms:
Adenosine 5'-monophosphoramidase | HINT | HINT1 | HINT1_HUMAN | Histidine triad nucleotide-binding protein 1 | PKCI-1 | PKCI1 | PRKCNH1 | Protein kinase C inhibitor 1 | Protein kinase C-interacting protein 1
Type:
PROTEIN
Mol. Mass.:
13803.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_795618
Residue:
126
Sequence:
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
  
Inhibitor
Name:
BDBM50535045
Synonyms:
CHEMBL4455776
Type:
Small organic molecule
Emp. Form.:
C27H38N8O8S
Mol. Mass.:
634.704
SMILES:
CCN(CC)CC.Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COS(=O)(=O)NC(=O)CCc2c[nH]c3ccccc23)[C@@H](O)[C@H]1O |r|
Structure:
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