Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 16
Ligand
BDBM50535058
Substrate
n/a
Meas. Tech.
ChEMBL_1929762 (CHEMBL4432938)
EC50
20±n/a nM
Citation
 Gibon, J; Kang, MS; Aliaga, A; Sharif, B; Rosa-Neto, P; Séguéla, P; Barker, PA; Kostikov, A Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorg Med Chem 24:4759-4765 (2016) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 16
Synonyms:
CD_antigen=CD271 | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | Ngfr | TNR16_MOUSE | Tnfrsf16 | Tumor necrosis factor receptor superfamily member 16
Type:
PROTEIN
Mol. Mass.:
45623.49
Organism:
Mus musculus
Description:
ChEMBL_119265
Residue:
427
Sequence:
MRRAGAACSAMDRLRLLLLLLLLLGVSFGGAKETCSTGMYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCSYGYYQDEETGRCEACSVCGVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWITRSTPPEGSDVTTPSTQEPEAPPERDLIASTVADTVTTVMGSSQPVVTRGTADNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV
  
Inhibitor
Name:
BDBM50535058
Synonyms:
CHEMBL4439582
Type:
Small organic molecule
Emp. Form.:
C12H25N3O2
Mol. Mass.:
243.3458
SMILES:
CCC(C)C(N)C(=O)NCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: