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Target
Aurora kinase B
Ligand
BDBM50535092
Substrate
n/a
Meas. Tech.
ChEMBL_1929868 (CHEMBL4433044)
IC50
79±n/a nM
Citation
 Garton, NS; Barker, MD; Davis, RP; Douault, C; Hooper-Greenhill, E; Jones, E; Lewis, HD; Liddle, J; Lugo, D; McCleary, S; Preston, AGS; Ramirez-Molina, C; Neu, M; Shipley, TJ; Somers, DO; Watson, RJ; Wilson, DM Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors. Bioorg Med Chem Lett 26:4606-4612 (2016) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50535092
Synonyms:
CHEMBL4469541
Type:
Small organic molecule
Emp. Form.:
C17H19N7O
Mol. Mass.:
337.3791
SMILES:
CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCCC(N)=O)n1
Structure:
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