Reaction Details
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Delta-type opioid receptor
Ligand
BDBM50091225
Substrate
n/a
Meas. Tech.
ChEMBL_147317 (CHEMBL755710)
Ki
4.7±n/a nM
Citation
Furness, MS; Zhang, X; Coop, A; Jacobson, AE; Rothman, RB; Dersch, CM; Xu, H; Porreca, F; Rice, KC Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers. J Med Chem 43:3193-6 (2000) [PubMed] Article More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
Inhibitor
Name:
BDBM50091225
Synonyms:
4-[(2,5-Dimethyl-4-pentyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide | CHEMBL108543
Type:
Small organic molecule
Emp. Form.:
C30H45N3O2
Mol. Mass.:
479.6972
SMILES:
CCCCCN1C[C@H](C)N(C[C@H]1C)C(c1ccc(cc1)C(=O)N(CC)CC)c1cccc(OC)c1
Structure:
