Reaction Details Report a problem with these data
Target
Vitamin K epoxide reductase complex subunit 1
Ligand
BDBM50535486
Substrate
n/a
Meas. Tech.
ChEMBL_1930830 (CHEMBL4434081)
IC50
1929±n/a nM
Citation
 Xing, H; Houston, SD; Chen, X; Jin, DY; Savage, GP; Tie, JK; Williams, CM Determining the necessity of phenyl ring ?-character in warfarin. Bioorg Med Chem Lett 29:1954-1956 (2019) [PubMed]  Article 
Target
Name:
Vitamin K epoxide reductase complex subunit 1
Synonyms:
VKOR | VKOR1_HUMAN | VKORC1 | Vitamin K epoxide reductase complex subunit 1 | Vitamin K epoxide reductase complex subunit 1 (hVKORC1) | Vitamin K1 2,3-epoxide reductase subunit 1 | Vitamin k epoxide reductase complex subunit 1 isoform 1
Type:
Enzyme
Mol. Mass.:
18244.90
Organism:
Homo sapiens (Human)
Description:
Q9BQB6
Residue:
163
Sequence:
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
  
Inhibitor
Name:
BDBM50535486
Synonyms:
CHEMBL4463800
Type:
Small organic molecule
Emp. Form.:
C22H18O6
Mol. Mass.:
378.3747
SMILES:
CC(=O)CC(c1c(O)c2ccccc2oc1=O)/C1=C/C=C(\C=C/C=C\1)/C(O)=O |c:21,23,25,t:19|
Structure:
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