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Target
Cyclin-dependent kinase 14
Ligand
BDBM50535530
Substrate
n/a
Meas. Tech.
ChEMBL_1930927 (CHEMBL4434178)
IC50
>1000±n/a nM
Citation
 Ferguson, FM; Doctor, ZM; Ficarro, SB; Marto, JA; Kim, ND; Sim, T; Gray, NS Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14. Bioorg Med Chem Lett 29:1985-1993 (2019) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 14
Synonyms:
CDK14 | CDK14_HUMAN | KIAA0834 | PFTK1 | Serine/threonine-protein kinase PFTAIRE-1
Type:
PROTEIN
Mol. Mass.:
53075.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774550
Residue:
469
Sequence:
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
  
Inhibitor
Name:
BDBM50535530
Synonyms:
CHEMBL4464758
Type:
Small organic molecule
Emp. Form.:
C32H38F3N7O9S
Mol. Mass.:
753.746
SMILES:
OC(=O)C(F)(F)F.COc1cccc(OC)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCN(CC1)S(=O)(=O)c1cccc(NC(=O)\C=C\CN(C)C)c1
Structure:
Search PDB for entries with ligand similarity: