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Target
Cyclin-dependent kinase 14
Ligand
BDBM50535582
Substrate
n/a
Meas. Tech.
ChEMBL_1930927 (CHEMBL4434178)
IC50
>1000±n/a nM
Citation
 Ferguson, FM; Doctor, ZM; Ficarro, SB; Marto, JA; Kim, ND; Sim, T; Gray, NS Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14. Bioorg Med Chem Lett 29:1985-1993 (2019) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 14
Synonyms:
CDK14 | CDK14_HUMAN | KIAA0834 | PFTK1 | Serine/threonine-protein kinase PFTAIRE-1
Type:
PROTEIN
Mol. Mass.:
53075.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774550
Residue:
469
Sequence:
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
  
Inhibitor
Name:
BDBM50535582
Synonyms:
CHEMBL4584359
Type:
Small organic molecule
Emp. Form.:
C30H32Cl2F3N7O7S
Mol. Mass.:
762.584
SMILES:
OC(=O)C(F)(F)F.CN(C)CC\C=C\C(=O)Nc1ccc(cc1)S(=O)(=O)N1CC[C@H](C1)NC(=O)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl |r|
Structure:
Search PDB for entries with ligand similarity: