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Target
Endothelin-1 receptor
Ligand
BDBM50091520
Substrate
n/a
Meas. Tech.
ChEBML_63344
IC50
530±n/a nM
Citation
 Kanda, Y; Takahashi, T; Araki, Y; Konoike, T; Mihara, S; Fujimoto, M Discovery and synthesis of a potent sulfonamide ET(B) selective antagonist. Bioorg Med Chem Lett 10:1875-8 (2000) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50091520
Synonyms:
4-tert-Butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-methyl-isoxazol-3-yl]-benzenesulfonamide | CHEMBL59425
Type:
Small organic molecule
Emp. Form.:
C21H24N2O4S2
Mol. Mass.:
432.556
SMILES:
COc1cccc(Sc2c(C)onc2NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c1
Structure:
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