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Target
D(2) dopamine receptor
Ligand
BDBM50091632
Substrate
n/a
Meas. Tech.
ChEMBL_61430 (CHEMBL671404)
IC50
14000±n/a nM
Citation
 Wright, JL; Gregory, TF; Kesten, SR; Boxer, PA; Serpa, KA; Meltzer, LT; Wise, LD; Espitia, SA; Konkoy, CS; Whittemore, ER; Woodward, RM Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J Med Chem 43:3408-19 (2000) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50091632
Synonyms:
5-{3-[4-(4-Methyl-benzyl)-piperidin-1-yl]-prop-1-ynyl}-1,3-dihydro-benzoimidazol-2-one | CHEMBL419399
Type:
Small organic molecule
Emp. Form.:
C23H25N3O
Mol. Mass.:
359.4641
SMILES:
Cc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)[nH]c4c3)CC2)cc1
Structure:
Search PDB for entries with ligand similarity: