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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50091703
Substrate
n/a
Meas. Tech.
ChEMBL_205056 (CHEMBL810250)
IC50
1450±n/a nM
Citation
 Abell, AD; Prince, MJ; McNulty, AM; Neubauer, BL Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett 10:1909-11 (2001) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50091703
Synonyms:
(4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinoline-3-thione | CHEMBL55260
Type:
Small organic molecule
Emp. Form.:
C14H17NS
Mol. Mass.:
231.356
SMILES:
CN1[C@@H]2CCc3ccccc3[C@H]2CCC1=S
Structure:
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