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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50070051
Substrate
n/a
Meas. Tech.
ChEBML_204907
IC50
180±n/a nM
Citation
 Abell, AD; Prince, MJ; McNulty, AM; Neubauer, BL Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett 10:1909-11 (2001) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50070051
Synonyms:
(4aR,10bR)-4,10b-Dimethyl-8-((E)-styryl)-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | CHEMBL300446
Type:
Small organic molecule
Emp. Form.:
C23H25NO
Mol. Mass.:
331.4507
SMILES:
CN1[C@@H]2CCc3cc(\C=C\c4ccccc4)ccc3[C@@]2(C)CCC1=O
Structure:
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