Reaction Details Report a problem with these data
Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50059084
Substrate
n/a
Meas. Tech.
ChEMBL_1931300 (CHEMBL4434551)
IC50
130±n/a nM
Citation
 Tasker, NR; Rastelli, EJ; Burnett, JC; Sharlow, ER; Lazo, JS; Wipf, P Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors. Bioorg Med Chem Lett 29:2008-2015 (2019) [PubMed]  Article 
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50059084
Synonyms:
CHEMBL3393171 | US10308663, Thienopyridone (5)
Type:
Small organic molecule
Emp. Form.:
C13H10N2OS
Mol. Mass.:
242.296
SMILES:
Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: