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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50535796
Substrate
n/a
Meas. Tech.
ChEMBL_1931748 (CHEMBL4477400)
IC50
9900±n/a nM
Citation
 Wang, GC; Yu, JH; Shen, Y; Leng, Y; Zhang, H; Yue, JM Limonoids and Triterpenoids as 11?-HSD1 Inhibitors from Walsura robusta. J Nat Prod 79:899-906 (2016) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50535796
Synonyms:
CHEMBL4575439
Type:
Small organic molecule
Emp. Form.:
C28H32O7
Mol. Mass.:
480.5495
SMILES:
[H][C@@]12C[C@@H](c3ccoc3)[C@]3(C)C[C@H](OC(C)=O)[C@]4([H])[C@@]5(C)C=CC(=O)C(C)(C)C5=C(O)C(=O)[C@@]4(C)[C@@]13O2 |r,c:22,t:30|
Structure:
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