Reaction Details Report a problem with these data
Target
Erythropoietin receptor
Ligand
BDBM50091850
Substrate
n/a
Meas. Tech.
ChEBML_67869
IC50
7000±n/a nM
Citation
 Connolly, PJ; Wetter, SK; Murray, WV; Johnson, DL; McMahon, FJ; Farrell, FX; Tullai, J; Jolliffe, LK Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids. Bioorg Med Chem Lett 10:1995-9 (2001) [PubMed]  Article 
Target
Name:
Erythropoietin receptor
Synonyms:
EPO-R | EPOR | EPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
55040.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_67864
Residue:
508
Sequence:
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
  
Inhibitor
Name:
BDBM50091850
Synonyms:
CHEMBL415681 | N-((S)-5-[Bis-(4-benzyloxy-benzyl)-amino]-5-{3-[2-(2-{3-[(S)-2-[bis-(4-benzyloxy-benzyl)-amino]-6-(3-carboxy-propionylamino)-hexanoylamino]-propoxy}-ethoxy)-ethoxy]-propylcarbamoyl}-pentyl)-succinamic acid
Type:
Small organic molecule
Emp. Form.:
C86H104N6O15
Mol. Mass.:
1461.7772
SMILES:
OC(=O)CCC(=O)NCCCC[C@H](N(Cc1ccc(OCc2ccccc2)cc1)Cc1ccc(OCc2ccccc2)cc1)C(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CCCCNC(=O)CCC(O)=O)N(Cc1ccc(OCc2ccccc2)cc1)Cc1ccc(OCc2ccccc2)cc1
Structure:
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