Reaction Details Report a problem with these data
Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50535809
Substrate
n/a
Meas. Tech.
ChEMBL_1931814 (CHEMBL4477466)
EC50
39600±n/a nM
Citation
 Lavey, NP; Coker, JA; Ruben, EA; Duerfeldt, AS Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. J Nat Prod 79:1193-7 (2016) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
ATP-dependent Clp protease proteolytic subunit | CLPP_ECOLI | Caseinolytic protease | Endopeptidase Clp | Heat shock protein F21.5 | JW0427 | Protease Ti | clpP | lopP
Type:
PROTEIN
Mol. Mass.:
23183.39
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_109492
Residue:
207
Sequence:
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
  
Inhibitor
Name:
BDBM50535809
Synonyms:
Sclerotiamide
Type:
Small organic molecule
Emp. Form.:
C26H29N3O5
Mol. Mass.:
463.5256
SMILES:
[H][C@@]12C[C@]34CCCN3C(=O)[C@]1(NC4=O)[C@@H](O)[C@@]1(C(=O)Nc3c1ccc1OC(C)(C)C=Cc31)C2(C)C |r,c:33,THB:13:12:1.2:8.7|
Structure:
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