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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50535811
Substrate
n/a
Meas. Tech.
ChEMBL_1931813 (CHEMBL4477465)
EC50
1200±n/a nM
Citation
 Lavey, NP; Coker, JA; Ruben, EA; Duerfeldt, AS Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. J Nat Prod 79:1193-7 (2016) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
ATP-dependent Clp protease proteolytic subunit | CLPP_ECOLI | Caseinolytic protease | Endopeptidase Clp | Heat shock protein F21.5 | JW0427 | Protease Ti | clpP | lopP
Type:
PROTEIN
Mol. Mass.:
23183.39
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_109492
Residue:
207
Sequence:
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
  
Inhibitor
Name:
BDBM50535811
Synonyms:
CHEMBL4549588
Type:
Small organic molecule
Emp. Form.:
C47H57N7O11
Mol. Mass.:
895.9958
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](COC(=O)[C@]1([H])C[C@@H](C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\C=C\C=C\C=C\C=C\C(=O)NC1=C(O)CCC1=O |r,c:64|
Structure:
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