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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50535810
Substrate
n/a
Meas. Tech.
ChEMBL_1931814 (CHEMBL4477466)
EC50
25400±n/a nM
Citation
 Lavey, NP; Coker, JA; Ruben, EA; Duerfeldt, AS Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. J Nat Prod 79:1193-7 (2016) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
ATP-dependent Clp protease proteolytic subunit | CLPP_ECOLI | Caseinolytic protease | Endopeptidase Clp | Heat shock protein F21.5 | JW0427 | Protease Ti | clpP | lopP
Type:
PROTEIN
Mol. Mass.:
23183.39
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_109492
Residue:
207
Sequence:
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
  
Inhibitor
Name:
BDBM50535810
Synonyms:
CHEMBL4593796
Type:
Small organic molecule
Emp. Form.:
C17H17BrCl2O4
Mol. Mass.:
436.124
SMILES:
[#6]-[#6]-[#8]-[#6](=O)-[#6@H]-1-[#6@@H](-[#6][C@@]([#8])([#6]-[#6]-1=O)c1ccc(Br)cc1)\[#6]=[#6](\Cl)Cl |r|
Structure:
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