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Target
Serine palmitoyltransferase 1
Ligand
BDBM50535847
Substrate
n/a
Meas. Tech.
ChEMBL_1932328 (CHEMBL4477980)
IC50
64±n/a nM
Citation
 Genin, MJ; Gonzalez Valcarcel, IC; Holloway, WG; Lamar, J; Mosior, M; Hawkins, E; Estridge, T; Weidner, J; Seng, T; Yurek, D; Adams, LA; Weller, J; Reynolds, VL; Brozinick, JT Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem 59:5904-10 (2016) [PubMed]  Article 
Target
Name:
Serine palmitoyltransferase 1
Synonyms:
LCB 1 | LCB1 | Long chain base biosynthesis protein 1 | SPT 1 | SPT1 | SPTC1_HUMAN | SPTLC1 | Serine-palmitoyl-CoA transferase 1
Type:
PROTEIN
Mol. Mass.:
52739.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_660503
Residue:
473
Sequence:
MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
  
Inhibitor
Name:
BDBM50535847
Synonyms:
CHEMBL4541898
Type:
Small organic molecule
Emp. Form.:
C24H33N3O3
Mol. Mass.:
411.5371
SMILES:
CCCCCCC(=O)N1CCc2c(C1)c(nn2C)-c1ccc(cc1)C(C)(C)C(O)=O
Structure:
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