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Target
Serine/threonine-protein kinase TAO2
Ligand
BDBM50536358
Substrate
n/a
Meas. Tech.
ChEMBL_1933645 (CHEMBL4479297)
IC50
800±n/a nM
Citation
 Piala, AT; Akella, R; Potts, MB; Dudics-Giagnocavo, SA; He, H; Wei, S; White, MA; Posner, BA; Goldsmith, EJ Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorg Med Chem Lett 26:3923-7 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase TAO2
Synonyms:
2.7.11.1 | Serine/threonine-protein kinase TAO2 | TAOK2_RAT | Tao2 | Taok2 | Thousand and one amino acid protein 2
Type:
PROTEIN
Mol. Mass.:
138761.39
Organism:
Rattus norvegicus
Description:
ChEMBL_119215
Residue:
1235
Sequence:
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMGLPATGALGPLSTGTLSEEQPCSSGQEAILGQRMLGEEEEAVPERMILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLVNEEDWDISKEMKESRVPSLASQERNIIGQEEAGAWNLWEKEHGNLVDMEFKLGWVQGPVLTPVPEEEEEEEEEGGAPIGTPRDPGDGCPSPDIPPEPPPSHLRQYPASQLPGFLSHGLLTGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPSLFLLLAQGTALGAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMRRGISRLWLRVLLRLSPMVFRALQGCAAVGDRGLFALYPKTNKNGFRSRLPVPWPRQGNPRTTQHPLALLARVWALCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLLPRSQRRLGLSASRQLPPGTVAGRRSQTRRALPPWR
  
Inhibitor
Name:
BDBM50536358
Synonyms:
CHEMBL2164269
Type:
Small organic molecule
Emp. Form.:
C20H17N5O3S3
Mol. Mass.:
471.576
SMILES:
Cc1nc(NC(=O)c2ccccc2)sc1-c1csc(Nc2ccc(cc2)S(N)(=O)=O)n1
Structure:
Search PDB for entries with ligand similarity: