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Target
D(2) dopamine receptor
Ligand
BDBM50092451
Substrate
n/a
Meas. Tech.
ChEMBL_61577 (CHEMBL675091)
IC50
35±n/a nM
Citation
 Mayer, P; Brunel, P; Chaplain, C; Piedecoq, C; Calmel, F; Schambel, P; Chopin, P; Wurch, T; Pauwels, PJ; Marien, M; Vidaluc, JL; Imbert, T New substituted 1-(2,3-dihydrobenzo[1, 4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with alpha(2)-adrenoceptor antagonist activity. J Med Chem 43:3653-64 (2000) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50092451
Synonyms:
1-Cyclohexyl-3-{2-[1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-ethyl}-urea | CHEMBL122215
Type:
Small organic molecule
Emp. Form.:
C23H35N3O3
Mol. Mass.:
401.5423
SMILES:
O=C(NCCC1CCN(CC2COc3ccccc3O2)CC1)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: