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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50537082
Substrate
n/a
Meas. Tech.
ChEMBL_1935714 (CHEMBL4481473)
EC50
170±n/a nM
Citation
 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a ?M MC4R Partial Agonist. J Med Chem 62:2738-2749 (2019) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50537082
Synonyms:
CHEMBL4538209
Type:
Small organic molecule
Emp. Form.:
C31H39ClN6O6
Mol. Mass.:
627.131
SMILES:
CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O |r|
Structure:
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