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Target
Coagulation factor X
Ligand
BDBM50537844
Substrate
n/a
Meas. Tech.
ChEMBL_1971484 (CHEMBL4604302)
IC50
3.4±n/a nM
Citation
 Shi, Y; Pan, BW; Li, WC; Wang, Q; Wu, Q; Pan, M; Fu, HZ Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50537844
Synonyms:
CHEMBL4643136
Type:
Small organic molecule
Emp. Form.:
C24H30ClN7O4S
Mol. Mass.:
548.057
SMILES:
CN(C)C(=O)[C@@H]1CC[C@@H](NC(=O)c2nc3CCN(C)Cc3s2)[C@H](C1)NC(=O)C(=O)Nc1ccc(Cl)cn1 |r|
Structure:
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