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Target
Chymase
Ligand
BDBM50093732
Substrate
n/a
Meas. Tech.
ChEBML_197657
IC50
>10000±n/a nM
Citation
 Aoyama, Y; Uenaka, M; Konoike, T; Iso, Y; Nishitani, Y; Kanda, A; Naya, N; Nakajima, M 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma. Bioorg Med Chem Lett 10:2403-6 (2001) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50093732
Synonyms:
(6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester | CHEMBL80190
Type:
Small organic molecule
Emp. Form.:
C25H26N2O7
Mol. Mass.:
466.4831
SMILES:
CO[C@]1(NC(=O)Cc2ccc(O)cc2)[C@H]2OCC(C)=C(N2C1=O)C(=O)OCc1cccc(C)c1 |c:19|
Structure:
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