Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50093767
Substrate
n/a
Meas. Tech.
ChEBML_40297
Kd
7600±n/a nM
Citation
 Artis, DR; Brotherton-Pleiss, C; Pease, JH; Lin, CJ; Ferla, SW; Newman, SR; Bhakta, S; Ostrelich, H; Jarnagin, K Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor. Bioorg Med Chem Lett 10:2421-5 (2001) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50093767
Synonyms:
1-(3-Aminomethyl-benzyl)-6,6-dibenzyl-1,4,5,6-tetrahydro-indol-7-one | CHEMBL309221
Type:
Small organic molecule
Emp. Form.:
C30H30N2O
Mol. Mass.:
434.572
SMILES:
NCc1cccc(Cn2ccc3CCC(Cc4ccccc4)(Cc4ccccc4)C(=O)c23)c1
Structure:
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