Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50093771
Substrate
n/a
Meas. Tech.
ChEBML_40297
Kd
5000±n/a nM
Citation
 Artis, DR; Brotherton-Pleiss, C; Pease, JH; Lin, CJ; Ferla, SW; Newman, SR; Bhakta, S; Ostrelich, H; Jarnagin, K Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor. Bioorg Med Chem Lett 10:2421-5 (2001) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50093771
Synonyms:
CHEMBL79057 | N-[(S)-1-(4-Butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-4-guanidinomethyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C26H37N5O
Mol. Mass.:
435.6049
SMILES:
CCCCc1ccnc(c1)[C@H](CC1CCCCC1)NC(=O)c1ccc(CNC(N)=N)cc1
Structure:
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