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Target
Isocitrate lyase
Ligand
BDBM50537888
Substrate
n/a
Meas. Tech.
ChEMBL_1971676 (CHEMBL4604494)
IC50
22000±n/a nM
Citation
 Bae, J; Cho, E; Park, JS; Won, TH; Seo, SY; Oh, DC; Oh, KB; Shin, J Isocadiolides A-H: Polybrominated Aromatics from a  J Nat Prod 83:429-437 (2020) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_CANAX | ICL1
Type:
PROTEIN
Mol. Mass.:
61398.95
Organism:
Candida albicans
Description:
ChEMBL_972063
Residue:
550
Sequence:
MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA
  
Inhibitor
Name:
BDBM50537888
Synonyms:
CHEMBL4634710
Type:
Small organic molecule
Emp. Form.:
C25H12Br6O7
Mol. Mass.:
903.783
SMILES:
COC(=O)C1=C(C(=O)C(C1=O)(c1cc(Br)c(O)c(Br)c1)c1cc(Br)c(O)c(Br)c1)c1cc(Br)c(O)c(Br)c1 |t:4|
Structure:
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