Reaction Details Report a problem with these data
Target
Cyclin-K
Ligand
BDBM50538124
Substrate
n/a
Meas. Tech.
ChEMBL_1972305 (CHEMBL4605123)
IC50
1120±n/a nM
Citation
 Wang, Y; Chen, X; Yan, Y; Zhu, X; Liu, M; Liu, X Discovery and SARs of 5-Chloro- J Med Chem 63:3327-3347 (2020) [PubMed]  Article 
Target
Name:
Cyclin-K
Synonyms:
CCNK | CCNK_HUMAN | CPR4
Type:
PROTEIN
Mol. Mass.:
64254.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107901
Residue:
580
Sequence:
MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR
  
Inhibitor
Name:
BDBM50538124
Synonyms:
CHEMBL4639374
Type:
Small organic molecule
Emp. Form.:
C21H22ClN5O
Mol. Mass.:
395.885
SMILES:
Cc1ccccc1Nc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1Cl
Structure:
Search PDB for entries with ligand similarity: