Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 2
Ligand
BDBM50538253
Substrate
n/a
Meas. Tech.
ChEMBL_1972489 (CHEMBL4605307)
Ki
263±n/a nM
Citation
 Mudd, GE; Brown, A; Chen, L; van Rietschoten, K; Watcham, S; Teufel, DP; Pavan, S; Lani, R; Huxley, P; Bennett, GS Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads. J Med Chem 63:4107-4116 (2020) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 2
Synonyms:
ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK
Type:
PROTEIN
Mol. Mass.:
108260.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1505248
Residue:
976
Sequence:
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
  
Inhibitor
Name:
BDBM50538253
Synonyms:
CHEMBL4638393
Type:
Small organic molecule
Emp. Form.:
C89H121N23O18S3
Mol. Mass.:
1897.251
SMILES:
[H][C@@]12CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@]1([H])CCCN1C(=O)[C@H](CSCc1cc3CSC[C@H](NC(=O)[C@@]([H])(NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@@H](NC(=O)[C@]4([H])CCCN4C(=O)[C@]([H])(CSCc(c3)c1)NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](C)NC2=O)C(C)C)[C@H](C)O)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](C)N |r|
Structure:
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