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Target
Substance-P receptor
Ligand
BDBM50094143
Substrate
n/a
Meas. Tech.
ChEMBL_208672 (CHEMBL813331)
IC50
2.8±n/a nM
Citation
 Vedani, A; Briem, H; Dobler, M; Dollinger, H; McMasters, DR Multiple-conformation and protonation-state representation in 4D-QSAR: the neurokinin-1 receptor system. J Med Chem 43:4416-27 (2000) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50094143
Synonyms:
2-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(4-cyclohexyl-piperazin-1-yl)-2-naphthalen-1-yl-ethyl]-acetamide | CHEMBL136411
Type:
Small organic molecule
Emp. Form.:
C32H35F6N3O
Mol. Mass.:
591.6302
SMILES:
FC(F)(F)c1cc(CC(=O)NCC(N2CCN(CC2)C2CCCCC2)c2cccc3ccccc23)cc(c1)C(F)(F)F
Structure:
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